Situated in central Toledo, the Hostal Santo Tome is within an easy walk from Seminario de Toledo, City Hall and Toledo Cathedral. Toledo's attractions, such as Puerta del Sol and Alcazar de Toledo are easily accessible on foot.

The Hostal Santo Tome is only a minute from Church of Santo Tome. Only steps from the hotel are some of the town's most famous sites including Taller del Moro. Guests will find a wide variety of cafés and restaurants nearby. Museo de El Greco and Sefardi Museum are both five minutes away by foot.